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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.
Keywords: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1637-9
● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.
Keywords: Xylose fermentation Caproate Low temperature Bifidobacterium FAB pathway RBO pathway
Fully Self-driving Future Hits the Brakes
Chris Palmer
Engineering 2023, Volume 26, Issue 7, Pages 6-8 doi: 10.1016/j.eng.2023.05.002
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 714-728 doi: 10.1007/s11684-022-0959-5
Keywords: FRMD6 lung cancer mTOR pathway
Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine
Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu
Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 157-162 doi: 10.1007/s11684-011-0128-8
Keywords: evidence-based medicine clinical pathway methodology concept technical difficulty
Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation
Keywords: arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle
Webb Space Telescope Hits Its Stride, Dazzling Astronomers
Mitch Leslie
Engineering 2023, Volume 22, Issue 3, Pages 3-6 doi: 10.1016/j.eng.2023.01.003
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 637-650 doi: 10.1007/s11684-021-0864-3
Keywords: apigenin aminoglycosides ototoxicity oxidative stress Nrf2 signaling pathway
Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus
Xiaoxuan Zhu,Xinyi Zeng,Chao Sun,Shilin Chen
Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 285-293 doi: 10.1007/s11684-014-0350-2
Keywords: Catharanthus roseus terpenoidindole alkaloids biosynthetic pathway vinblastine vincristine
Genetic evidence in planar cell polarity signaling pathway in human neural tube defects
Chunquan Cai, Ouyan Shi
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 68-78 doi: 10.1007/s11684-014-0308-4
Keywords: planar cell polarity neural tube defects rare mutations
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 263-274 doi: 10.1007/s11684-022-0935-0
Keywords: melanoma neuropilin and tolloid-like 2 Ca2+/CaMKII signaling pathway
Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma
Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 688-696 doi: 10.1007/s11684-018-0662-8
Keywords: XKQ type 2 diabetes mellitus KKAy mice PI3K/Akt pathway diabetic liver disease
Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma
ZHANG Xufeng, YU Liang, LU Yi
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 216-228 doi: 10.1007/s11684-008-0042-x
Keywords: interacting complicated understanding embryogenesis activation organism development
Analysis of a Peaked Carbon Emission Pathway in China Toward Carbon Neutrality
Project Team on the Strategy and Pathway for Peaking Carbon Emissions and Carbon Neutrality
Engineering 2021, Volume 7, Issue 12, Pages 1673-1677 doi: 10.1016/j.eng.2021.10.003
Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 534-548 doi: 10.1007/s11684-022-0953-y
Keywords: autoimmune hepatitis (AIH) concanavalin A (Con A) human menstrual blood-derived stem cells (MenSCs) apoptosis mitogen-activated protein kinase (MAPK)
Title Author Date Type Operation
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Journal Article
Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation
Journal Article
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression
Journal Article
Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine
Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu
Journal Article
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma
Journal Article
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair
Journal Article
Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus
Xiaoxuan Zhu,Xinyi Zeng,Chao Sun,Shilin Chen
Journal Article
Genetic evidence in planar cell polarity signaling pathway in human neural tube defects
Chunquan Cai, Ouyan Shi
Journal Article
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
Journal Article
Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway
Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma
Journal Article
Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma
ZHANG Xufeng, YU Liang, LU Yi
Journal Article
Analysis of a Peaked Carbon Emission Pathway in China Toward Carbon Neutrality
Project Team on the Strategy and Pathway for Peaking Carbon Emissions and Carbon Neutrality
Journal Article